The paper revisits the key problematics of conceptualizing culture, the ethnographic relevance of cross cultural communication in business management, and the theoretical and pragmatic differences between glocalization, Euro-American and West African business management ethics and socioeconomic change in NEPAD (The New Partnership for African Development) countries. Further, it examines the power dynamics of the local sub-cultures (manager, employee and local consumer) and the fundamental cultural differences between local and foreign managers and provides the contexts within which such core differences cultivate a hybrid business environment and enhance translocal negotiations. Finally, it discusses the triangular connection between hegemony, ICT and social change and identifies situations in urban W. African communities where local-foreign knowledge and technical resources promote globalization in the region.